학술논문
Iron Serum Markers Profile in Frontotemporal Lobar Degeneration.
Document Type
Letter
Author
Source
Subject
*BIOMARKERS
*FRONTOTEMPORAL lobar degeneration
*IRON
*CERULOPLASMIN
*NEURODEGENERATION
*TRANSFERRIN
*IRON metabolism
*RESEARCH
*BLOOD proteins
*FERRITIN
*RESEARCH methodology
*CASE-control method
*MEDICAL cooperation
*EVALUATION research
*APHASIA
*COMPARATIVE studies
*GLOBULINS
*FRONTOTEMPORAL dementia
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Language
ISSN
1387-2877
Abstract
Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative syndrome. Defects of copper (Cu) and iron (Fe) homeostasis are involved in the development of several neurodegenerative diseases and their homeostasis is interconnected by the Cu-protein ceruloplasmin (Cp), responsible for Fe oxidative state. In this study we assessed Fe, transferrin (Trf), ferritin, Cp specific activity (eCp/iCp), Cp/Trf ratio, and Trf saturation in 60 FTLD patients and 43 healthy controls, and discussed the results in relation to Cu homeostasis. The significant decrease of the eCp/iCp in the FTLD patients supports the involvement of Fe imbalance in the onset and progression of FTLD. [ABSTRACT FROM AUTHOR]