학술논문
Addition of dairy lipids and probiotic Lactobacillus fermentum in infant formula programs gut microbiota and entero-insular axis in adult minipigs.
Document Type
Article
Author
Lemaire, Marion; Dou, Samir; Cahu, Armelle; Formal, Michèle; Le Normand, Laurence; Romé, Véronique; Nogret, Isabelle; Ferret-Bernard, Stéphanie; Rhimi, Moez; Cuinet, Isabelle; Canlet, Cécile; Tremblay-Franco, Marie; Le Ruyet, Pascale; Baudry, Charlotte; Gérard, Philippe; Le Huërou-Luron, Isabelle; Blat, Sophie
Source
Subject
Language
ISSN
2045-2322
Abstract
Clinical and animal studies have demonstrated beneficial effects of early consumption of dairy lipids and a probiotic, Lactobacillus fermentum (Lf), on infant gut physiology. The objective of this study was to investigate their long-term effects on gut microbiota and host entero-insular axis and metabolism. Piglets were suckled with a milk formula containing only plant lipids (PL), a half-half mixture of plant lipids and dairy lipids (DL), or this mixture supplemented with Lf (DL + Lf). They were weaned on a standard diet and challenged with a high-energy diet until postnatal day 140. DL and DL + Lf modulated gut microbiota composition and metabolism, increasing abundance of several Clostridia genera. Moreover, DL + Lf specifically decreased the faecal content of 2-oxoglutarate and lysine compared to PL and 5-aminovalerate compared to PL and DL. It also increased short-chain fatty acid concentrations like propionate compared to DL. Furthermore, DL + Lf had a beneficial effect on the endocrine function, enhancing caecal GLP-1 and GLP-1 meal-stimulated secretion. Correlations highlighted the consistent relationship between microbiota and gut physiology. Together, our results evidence a beneficial programming effect of DL + Lf in infant formula composition on faecal microbiota and entero-insular axis function. [ABSTRACT FROM AUTHOR]