부산대학교 도서관

Abstract Background Elevated fibrinogen levels have been linked to increased risk for deep venous thrombosis, although it is not clear whether fibrinogen is causal or rather a marker for the presence of other risk factors. A common G/A polymorphism in the gene for the fibrinogen beta-chain (FGB G-455A) is associated with elevated fibrinogen levels. The present study was designed to analyze the role of this genetic marker for deep venous thrombosis. Materials and Methods We performed a case–control study including 307 patients with documented deep venous thrombosis and 316 control subjects. β-fibrinogen genotypes were determined by allele-specific polymerase chain reaction. Results GG, GA and AA genotype frequencies were similar among the patients (53·1%, 41·0, 5·9) and controls (51·6%, 42·1, 6·3; P = 0·92). Fibrinogen levels of the patients (median 3·72 g l-1 ; range 1·93–11·6) did not differ significantly from those of the controls (3·76; 2·17–9·99). Carriers of the homozygous AA genotype had significantly higher fibrinogen levels than noncarriers (patients: 5·32 vs. 3·59; P = 0·024; controls: 6·29 vs. 3·72; P = 0·048). Conclusion Our data suggest that the fibrinogen-elevating FGB G-455A gene polymorphism is not linked to an increased risk for deep venous thrombosis. [ABSTRACT FROM AUTHOR]