부산대학교 도서관

Simple Summary: Pancreatic neuroendocrine tumors (PNETs) represent a small portion of pancreatic neoplasms and can manifest as either functional or non-functional. Managing these tumors presents a challenge due to their rarity and heterogenous tumor biology. This manuscript offers a comprehensive review of PNET types, classification, and management strategies, with a focus on the evolving landscape of pancreatic surgery. It aims to assist clinicians in facilitating the management of these increasingly common tumors and optimizing patient outcomes. The incidence of pancreatic neuroendocrine tumors (PNETs) is on the rise primarily due to the increasing use of cross-sectional imaging. Most of these incidentally detected lesions are non-functional PNETs with a small proportion of lesions being hormone-secreting, functional neoplasms. With recent advances in surgical approaches and systemic therapies, the management of PNETs have undergone a paradigm shift towards a more individualized approach. In this manuscript, we review the histologic classification and diagnostic approaches to both functional and non-functional PNETs. Additionally, we detail multidisciplinary approaches and surgical considerations tailored to the tumor's biology, location, and functionality based on recent evidence. We also discuss the complexities of metastatic disease, exploring liver-directed therapies and the evolving landscape of minimally invasive surgical techniques. [ABSTRACT FROM AUTHOR]