부산대학교 도서관

Plasma of COVID-19 patients contains a strong metabolomic/lipoproteomic signature, revealed by the NMR analysis of a cohort of >500 patients sampled during various waves of COVID-19 infection, corresponding to the spread of different variants, and having different vaccination status. This composite signature highlights common traits of the SARS-CoV-2 infection. The most dysregulated molecules display concentration trends that scale with disease severity and might serve as prognostic markers for fatal events. Metabolomics evidence is then used as input data for a sex-specific multi-organ metabolic model. This reconstruction provides a comprehensive view of the impact of COVID-19 on the entire human metabolism. The human (male and female) metabolic network is strongly impacted by the disease to an extent dictated by its severity. A marked metabolic reprogramming at the level of many organs indicates an increase in the generic energetic demand of the organism following infection. Sex-specific modulation of immune response is also suggested. Author summary: Metabolites and lipoproteins are the main components of human plasma and their concentration can be determined by nuclear magnetic resonance. In COVID-19 patients there are significant alterations in the concentration of several of these molecules. Using the plasma of more than 600 subjects (510 patients sampled in the acute phase of the infection plus 95 independent recovered subjects), we demonstrate that the dysregulation of these molecules is a function of the disease severity but it is not affected by either the SARS-CoV-2 variants or the vaccination status. The disease signature is particularly evident in those cases that subsequently evolve towards a fatal outcome, and could have prognostic value. Building on this large amount of data, we propose a metabolic reconstruction of the disease using a sex-specific multi-organ metabolic model. [ABSTRACT FROM AUTHOR]