학술논문
A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases.
Document Type
Article
Author
Source
Subject
*POLYMERASES
*RNA polymerases
*TICK-borne encephalitis viruses
*RNA synthesis
*COVID-19 pandemic
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Language
ISSN
1420-3049
Abstract
Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many +RNA viruses are urgently needed. Here, we present PR673, a helquat-like compound that is able to inhibit the replication of SARS-CoV-2 and tick-borne encephalitis virus in cell culture. Using in vitro polymerase assays, we demonstrate that PR673 inhibits RNA synthesis by viral RNA-dependent RNA polymerases (RdRps). Our results illustrate that the development of broad-spectrum non-nucleoside inhibitors of RdRps is feasible. [ABSTRACT FROM AUTHOR]