학술논문
Exonuclease Domain of the Lassa Virus Nucleoprotein Is Critical To Avoid RIG-I Signaling and To Inhibit the Innate Immune Response.
Document Type
Article
Source
Subject
*EXONUCLEASES
*NUCLEOPROTEINS
*VIRAL proteins
*TRETINOIN
*VIRUS diseases
*IMMUNE response
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Language
ISSN
0022-538X
Abstract
Lassa virus (LASV), which causes a viral hemorrhagic fever, inhibits the innate immune response. The exonuclease (ExoN) domain of its nucleoprotein (NP) is implicated in the suppression of retinoic acid-inducible gene I (RIG-I) signaling. We show here that a LASV in which ExoN function has been abolished strongly activates innate immunity and that this effect is dependent on RIG-I signaling. These results highlight the key role of NP ExoN function in the immune evasion that occurs during LASV infection. [ABSTRACT FROM AUTHOR]