학술논문
Post-Irradiation Breast Angiosarcoma: All the Possible Treatments and Electrochemotherapy. Case Report and Literature Review.
Document Type
Article
Author
Parisi, Simona; Gambardella, Claudio; Iovino, Francesco; Ruggiero, Roberto; Lucido, Francesco Saverio; Nesta, Giusiana; Tolone, Salvatore; Brusciano, Luigi; Fisone, Francesca; Mongardini, Federico Maria; Cozzolino, Giovanni; Della Corte, Carminia Maria; Napolitano, Stefania; Orditura, Michele; Esposito, Rosetta; Docimo, Ludovico
Source
Subject
*ANGIOSARCOMA
*LITERATURE reviews
*NUCLEOTIDE sequencing
*PATIENT compliance
*INCURABLE diseases
*COMBINED modality therapy
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Language
ISSN
2077-0383
Abstract
Breast angiosarcoma is a rare malignancy, accounting for less than 1% of all soft tissue cancers. It comprises primitive and secondary subtypes, such as radiogenic breast angiosarcoma (RAS). Despite multimodal treatment, angiosarcomas represent an incurable disease for many patients and a significant cause of deterioration in their quality of life. Surgery is a cornerstone in management, but high recurrence rates are reported. Electrochemotherapy (ECT) is a practicable locoregional treatment for patients with advanced angiosarcoma as part of a multimodal therapeutic strategy. The palliative benefits of ECT include optimal patient compliance, good local hemostasis control, and positive local responses. Since only 22 cases are described in the literature, we reported a rare case of RAS treated with ECT after a multidisciplinary approach, including Next Generation Sequencing (NGS). A literature review on the feasibility of ECT in RAS management was also performed. [ABSTRACT FROM AUTHOR]