학술논문
Plasmodium falciparum genetic crosses in a humanized mouse model.
Document Type
Article
Author
Source
Subject
*PLASMODIUM falciparum
*DRUG resistance in microorganisms
*MALARIA
*CHLOROQUINE
*INSECT genetics
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Language
ISSN
1548-7091
Abstract
Genetic crosses of phenotypically distinct strains of the human malaria parasite Plasmodium falciparum are a powerful tool for identifying genes controlling drug resistance and other key phenotypes. Previous studies relied on the isolation of recombinant parasites from splenectomized chimpanzees, a research avenue that is no longer available. Here we demonstrate that human-liver chimeric mice support recovery of recombinant progeny for the identification of genetic determinants of parasite traits and adaptations. [ABSTRACT FROM AUTHOR]