학술논문
Multidrug-Resistant Bacterial Colonization and Infections in Large Retrospective Cohort of Mechanically Ventilated COVID-19 Patients.
Document Type
Article
Author
Mangioni, Davide; Chatenoud, Liliane; Colombo, Jacopo; Palomba, Emanuele; Guerrero, Fernando A.; Bolis, Matteo; Bottino, Nicola; Breda, Giuseppe; Chiaruttini, Maria V.; Fior, Gabriele; Marotta, Manuela; Massobrio, Giovanni; Matinato, Caterina; Muscatello, Antonio; Previtali, Paola; Santambrogio, Sara; Tardini, Francesca; Zuglian, Gianluca; Grasselli, Giacomo; Fumagalli, Roberto
Source
Subject
*COVID-19
*BACTERIAL colonies
*ARTIFICIAL respiration
*BACTERIAL diseases
*COVID-19 pandemic
*
*
*
*
Language
ISSN
1080-6040
Abstract
Few data are available on incidence of multidrug-resistant organism (MDRO) colonization and infections in mechanically ventilated patients, particularly during the COVID-19 pandemic. We retrospectively evaluated all patients admitted to the COVID-19 intensive care unit (ICU) of Hub Hospital in Milan, Italy, during October 2020-May 2021. Microbiologic surveillance was standardized with active screening at admission and weekly during ICU stay. Of 435 patients, 88 (20.2%) had MDROs isolated =48 h after admission. Of the remaining patients, MDRO colonization was diagnosed in 173 (51.2%), MDRO infections in 95 (28.1%), and non-MDRO infections in 212 (62.7%). Non-MDRO infections occurred earlier than MDRO infections (6 days vs. 10 days; p<0.001). Previous exposure to antimicrobial drugs within the ICU was higher in MDRO patients than in non-MDRO patients (116/197 [58.9%] vs. 18/140 [12.9%]; p<0.001). Our findings might serve as warnings for future respiratory viral pandemics and call for increased measures of antimicrobial stewardship and infection control. [ABSTRACT FROM AUTHOR]