학술논문
Platelet-rich plasma as treatment for persistent ocular epithelial defects.
Document Type
Article
Author
Source
Subject
*PLATELET-rich plasma
*CORNEA injuries
*GRAFT versus host disease
*PLATELET count
*FREEZING
*EYE drops
*THERAPEUTICS
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Language
ISSN
1473-0502
Abstract
Platelet- rich plasma (PRP) exhibits regenerative proprieties in wound healing but the biochemical mechanisms are unclear. In this study, autologous PRP with a mean value of 338 × 10 3 platelets/µL was used to treat corneal lesions of different aetiology, while homologous PRP with 1 × 10 6 platelets/µL was used to treat cornel lesions induced by a graft versus host disease. The impact of platelet count on the levels of PDGF AA and BB, VEGF, and EGF in the two PRPs was evaluated after a cycle of freezing/thawing. Treated corneal lesions healed or improved. The levels of PDGF AA and BB, VEGF, and EGF in the autologous PRP raised from 296 ± 61; 201.8 ± 24; 53 ± 14 and 8.9 ± 2 to 1017 ± 253; 924.7 ± 222; 101 ± 46.5 and 174 ± 15.5 pg/mL, while in the homologous PRP were 3.4, 4.5, 3.2 and 2 folds higher, respectively. High level of platelet counts seems not required to treat corneal lesions. [ABSTRACT FROM AUTHOR]