학술논문
Temporal Dynamics of Anti–Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019.
Document Type
Article
Author
Source
Subject
*AUTOANTIBODIES
*COMPUTER software
*RITUXIMAB
*COVID-19
*IMMUNOGLOBULINS
*CRITICALLY ill
*CONVALESCENCE
*PATIENTS
*INTERFERONS
*COMPARATIVE studies
*HEMATOPOIETIC stem cell transplantation
*LONGITUDINAL method
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Language
ISSN
1058-4838
Abstract
Binding levels and neutralization activity of anti–type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients maintained some ability to neutralize type 1 interferon into convalescence despite lower levels of binding immunoglobulin G. Identifying these autoantibodies in healthy individuals before the development of critical viral disease may be challenging. [ABSTRACT FROM AUTHOR]