학술논문

A self-consistent probabilistic formulation for inference of interactions.
Document Type
Article
Source
Scientific Reports. 12/8/2020, Vol. 10 Issue 1, p1-16. 16p.
Subject
*MOLECULAR interactions
*MEDICAL research
*AMBIVALENCE
*PROBABILITY theory
*MOLECULAR physics
Language
ISSN
2045-2322
Abstract
Large molecular interaction networks are nowadays assembled in biomedical researches along with important technological advances. Diverse interaction measures, for which input solely consisting of the incidence of causal-factors, with the corresponding outcome of an inquired effect, are formulated without an obvious mathematical unity. Consequently, conceptual and practical ambivalences arise. We identify here a probabilistic requirement consistent with that input, and find, by the rules of probability theory, that it leads to a model multiplicative in the complement of the effect. Important practical properties are revealed along these theoretical derivations, that has not been noticed before. [ABSTRACT FROM AUTHOR]