학술논문
Role of capsule endoscopy in alarm features and non‐responsive celiac disease: A European multicenter study.
Document Type
Article
Author
Perez‐Cuadrado‐Robles, Enrique; Lujan‐Sanchis, Marisol; Elli, Luca; Juanmartinena‐Fernandez, Jose‐Francisco; Garcıa‐Lledo, Javier; Ruano‐Dıaz, Lucıa; Egea‐Valenzuela, Juan; Jimenez‐Garcıa, Victoria‐Alejandra; Arguelles‐Arias, Federico; Juan‐Acosta, Mileidis San; Carretero‐Ribon, Cristina; Alonso‐Lazaro, Noelia; Rosa, Bruno; Sanchez‐Ceballos, Francisco; Lopez‐Higueras, Antonio; Fernandez‐Urien‐Sainz, Ignacio; Branchi, Federica; Valle‐Muñoz, Julio; Borque‐Barrera, Pilar; Gonzalez‐Vazquez, Santiago
Source
Subject
*CELIAC disease diagnosis
*CAPSULE endoscopy
*GLUTEN
*ENTEROSCOPY
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Language
ISSN
0915-5635
Abstract
Background and Aim: The role of capsule endoscopy (CE) in established celiac disease (CD) remains unclear. Our objective was to analyze the usefulness of CE in the suspicion of complicated CD. Methods: This was a retrospective multicenter study. One hundred and eighty‐nine celiac patients (mean age: 46.6 ± 16.6, 30.2% males) who underwent CE for alarm symptoms (n = 86, 45.5%) or non‐responsive CD (n = 103, 54.5%) were included. Diagnostic yield (DY), therapeutic impact and safety were analyzed. Results: Capsule endoscopy was completed in 95.2% of patients (small bowel transit time: 270.5 ± 100.2 min). Global DY was 67.2%, detecting atrophic mucosa (n = 92, 48.7%), ulcerative jejunoileitis (n = 21, 11.1%), intestinal lymphoma (n = 7, 3.7%) and other enteropathies (n = 7, 3.7%, six Crohn's disease cases and one neuroendocrine tumor). The DY of CE was significantly higher in patients presenting with non‐responsive disease compared to patients with alarm symptoms (73.8% vs 59.3%, P = 0.035). The new findings of the CE modified management in 59.3% of the cases. There were no major complications. Conclusion: Capsule endoscopy may be a moderately helpful and safe diagnostic tool in the suspicion of complicated CD, modifying the clinical course of these patients. [ABSTRACT FROM AUTHOR]