학술논문

Single-cell peripheral immunoprofiling of Alzheimer's and Parkinson's diseases.
Document Type
Article
Source
Science Advances. 11/25/2020, Vol. 6 Issue 48, p1-11. 11p.
Subject
*PARKINSON'S disease
*METHOXYPROPANOL
*SOMATOMEDIN C
Language
ISSN
2375-2548
Abstract
The article discusses peripheral blood mononuclear cells (PBMCs) providing insight to the pathogenesis of Alzheimer's disease (AD) or Parkinson's disease. Topics include data suggest enhanced PLC2 activity as a potential new therapeutic target for AD with a accessible pharmacodynamic biomarker; and three main intracellular signaling pathways have identified specifically in PBMC subsets from people with AD versus controls.