학술논문
Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage.
Document Type
Correction Notice
Author
Asken, Breton M.; Elahi, Fanny M.; La Joie, Renaud; Strom, Amelia; Staffaroni, Adam M.; Lindbergh, Cutter A.; Apple, Alexandra C.; You, Michelle; Weiner-Light, Sophia; Brathaban, Nivetha; Fernandes, Nicole; Karydas, Anna; Wang, Paul; Rojas, Julio C.; Boxer, Adam L.; Miller, Bruce L.; Rabinovici, Gil D.; Kramer, Joel H.; Casaletto, Kaitlin B.
Source
Subject
*GLIAL fibrillary acidic protein
*DISEASE progression
*OLDER people
*AMYLOID
*CEREBRAL amyloid angiopathy
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Language
ISSN
1387-2877
Abstract
In Cohort 2, we observed potential divergence of plasma GFAP and A -PET in the in older adults with CDR-SB>8.0, though the A -PET data in this CDR-SB range largely was extrapolated (green box). Controlling for plasma NfL somewhat attenuated the A -PET CL x CDR-SB interaction on plasma GFAP in Cohort 2 (R SP 2 sp change = .061, I p i = .05). In both Cohort 1 (A) and Cohort 2 (B), higher A -PET signal (measured in Centiloids; CLs) was associated with higher plasma GFAP in cases with CDR-SB=0 (yellow line) but not CDR-SB=0.5-4.0 (orange line). [Extracted from the article]