학술논문
Synthesis of Methylenebis(Phosphonate) Analogues of 2-, 4-, and 6-Pyridones of Nicotinamide Adenine Dinucleotide.
Document Type
Article
Source
Subject
*PHOSPHONATES
*PYRIDONE
*NICOTINAMIDE
*ORGANIC synthesis
*CELL membranes
*MOLECULAR probes
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Language
ISSN
1525-7770
Abstract
The synthesis of metabolically stable methylenebis(phosphonate) analogues of 2-, 4-, and 6-pyridones of nicotinamide adenine dinucleotide (NAD) is reported. In contrast to natural pyrophosphates, these NAD analogues are able to penetrate the cell membrane and can be used as probes in cellular assays. [ABSTRACT FROM AUTHOR]