학술논문
Risk Factors for Complicated Lymphadenitis Caused by Nontuberculous Mycobacteria in Children.
Document Type
Journal Article
Author
Kuntz, Martin; Kohlfürst, Daniela S.; Feiterna-Sperling, Cornelia; Krüger, Renate; Baumann, Ulrich; Buchtala, Laura; Elling, Roland; Grote, Veit; Hübner, Johannes; Hufnagel, Markus; Kaiser-Labusch, Petra; Liese, Johannes; Otto, Eva-Maria; Rose, Markus A.; Schneider, Christian; Schuster, Volker; Seidl, Maximilian; Sommerburg, Olaf; Vogel, Markus; von Bernuth, Horst
Source
Subject
*MYCOBACTERIA
*EMERGING infectious diseases
*LYMPHADENITIS
*AT-risk behavior
*LYMPH nodes
*MYCOBACTERIUM
*RESEARCH
*AGE distribution
*RESEARCH methodology
*ACQUISITION of data
*RETROSPECTIVE studies
*MEDICAL cooperation
*EVALUATION research
*SEASONS
*SEX distribution
*COMPARATIVE studies
*MYCOBACTERIAL diseases
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Language
ISSN
1080-6040
Abstract
Nontuberculous mycobacteria (NTM) are an emerging cause of infections, including chronic lymphadenitis in children. To identify risk factors for NTM lymphadenitis, particularly complicated disease, we collected epidemiologic, clinical, and microbiological data on 138 cases of NTM lymphadenitis in children across 13 centers in Germany and Austria. We assessed lifestyle factors but did not identify specific risk behaviors. We noted that more cases of NTM lymphadenitis occurred during cold months than during warm months. Moreover, we noted female sex and age <5.5 years as potential risk factors. Complete extirpation of the affected lymph node appeared to be the best therapeutic measure. We integrated the study data to develop a simple risk score to predict unfavorable clinical outcomes for NTM lymphadenitis. [ABSTRACT FROM AUTHOR]