학술논문
Building the Connectivity Map of epigenetics: Chromatin profiling by quantitative targeted mass spectrometry.
Document Type
Article
Author
Source
Subject
*MASS spectrometry
*NUCLEAR spectroscopy
*LABORATORY techniques
*EPIGENETICS
*MASS (Physics)
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Language
ISSN
1046-2023
Abstract
Epigenetic control of genome function is an important regulatory mechanism in diverse processes such as lineage commitment and environmental sensing, and in disease etiologies ranging from neuropsychiatric disorders to cancer. Here we report a robust, high-throughput targeted, quantitative mass spectrometry (MS) method to rapidly profile modifications of the core histones of chromatin that compose the epigenetic landscape, enabling comparisons among cells with differing genetic backgrounds, genomic perturbations, and drug treatments. [ABSTRACT FROM AUTHOR]