학술논문
Redefining neuroprotective gene therapeutic strategies: Lessons learned from caloric restriction and NAD^+ metabolism.
Document Type
Article
Author
Source
Subject
*CALORIC content of foods
*METABOLITES
*METABOLISM
*NAD (Coenzyme)
*PYRIDINE nucleotides
*ADENINE
*COENZYMES
*NICOTINAMIDE
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Language
ISSN
1387-2877
Abstract
Herein a case is made for the development of novel cytoprotective approaches based upon molecular mechanisms thought to underlie the caloric restriction phenomenon. This analysis leads to the prediction that molecular genetic perturbations affecting the metabolism of nuclear NAD^+ and metabolites will be neuroprotective. [ABSTRACT FROM AUTHOR]