부산대학교 도서관

Background: Zinc (Zn) is one of the essential nutrients that its metabolism changes in diabetes. It has been shown that there is a relationship between Zn and both kinds of diabetes [non-insulin-dependent diabetes mellitus (NIDDM) and insulin-dependent diabetes mellitus (IDDM)]. TNF-α and IL-6 relate with BMI and insulin resistance. It seems that there are relationships between Zn and TNF-α, IL-6, blood glucose and HbA1c. The aim of present study was to investigate relationship between serum zinc concentration and inflammatory intermediate, blood glucose and HbA1c in postmenopausal diabetic women. Methods: We studied 45 diabetic women and 45 healthy women (controls) with BMI 25-30 kg/m2 and aged 45-60 years. Fasting blood sugar (FBS), HbA1c, serum zinc, TNF-α, and IL-6, were determined in the two groups. Results: There were non significant positive correlations between Zn, IL-6 (r=0.28) and TNF-α (r= 0.03) and a non significant negative correlation between Zn and FBS (r= -0.06) and HbA1c (r= -0.07) in diabetic group. Conclusion: There were not a significant relationship between serum Zn and inflammatory intermediates (TNF-α, IL-6), FBS, and HbA1c in postmenopausal diabetic women. [ABSTRACT FROM AUTHOR]