학술논문
Antioxidant and antiplasmodial activities of methanol leaf extract of Paullinia pinnata.
Document Type
Article
Source
Subject
*ANIMAL experimentation
*ANTIMALARIALS
*ANTIOXIDANTS
*CHLOROQUINE
*HEPATITIS
*INFLAMMATION
*LEAVES
*LIVER
*LIVER function tests
*MEDICINAL plants
*METHANOL
*MICE
*RESEARCH funding
*PLANT extracts
*OXIDATIVE stress
*ALANINE aminotransferase
*DATA analysis software
*AMODIAQUINE
*PARASITEMIA
*ONE-way analysis of variance
*PHARMACODYNAMICS
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Language
ISSN
1049-6475
Abstract
The antiplasmodial effect of methanol extract of Paullinia pinnata leaves was investigated in mice to observe the outcome on oxidative stress and inflammation in the liver. Wistar mice of both sexes were used for the curative, prophylaxis, and suppressive tests by adopting standard procedures. In the curative test, the liver was processed for liver function, antioxidant, and anti-inflammatory assays and histology. Changes in percentage parasitemia was observed while the antioxidant and anti-inflammatory parameters were not affected. There was low suppressive activity, mildly moderate prophylactic potential, and curative property which were also reflected in the antioxidant and liver function test at higher dose while at a lower dose it showed weak curative activity with prophylactic and suppressive capacities. [ABSTRACT FROM AUTHOR]