학술논문

Nonoccupational Determinants of Plasma DDT and p,p'-DDE in Men from Chiapas, Mexico.
Document Type
Article
Source
Archives of Environmental Health. Jan2004, Vol. 59 Issue 1, p42-49. 8p.
Subject
*DDT (Insecticide)
*TOXICOLOGY
*METABOLITES
*ADIPOSE tissues
*BLOOD lipids
*ORGANOCHLORINE compounds
Language
ISSN
0003-9896
Abstract
The article focuses on a cross-sectional study that was conducted to evaluate non occupational biological exposure to 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) compounds and to identify the main factors associated with such exposure in a malaria endemic region in Mexico. Capillary gas column chromatography was used to determine levels of p,p'-DDT and its metabolites in plasma. The results of this study documented high p,p'-DDE and DDT levels in Mexican men from Chiapas in spite of the pesticide's severe restriction in 1987. DDT and its metabolites are stored in adipose tissue, and it has been reported that blood concentrations are influenced by blood lipid content. Thus, most literature adjusts blood organochlorine concentrations to lipid weight. Moreover, because organochlorines are stored in the adipose tissue, recent studies have reported that BMI, considered to be an important measure of obesity, is an important predictor of plasma concentrations of DDT in multivariate analyses.