학술논문
BIRC-3 mutated monoclonal B lymphocytosis without evolution to chronic lymphocytic leukemia (CLL).
Document Type
Article
Author
Source
Subject
*CHRONIC lymphocytic leukemia
*LYMPHOCYTOSIS
*SOMATIC mutation
*MONOCLONAL gammopathies
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Language
ISSN
1042-8194
Abstract
This letter to the editor discusses the case of a 76-year-old patient who was evaluated for a possible lymphoid malignancy. The patient had a history of gastrointestinal stromal tumor (GIST) and was treated with Imatinib, which led to complete remission. Further examination revealed the presence of a B-cell clone in the peripheral blood, but over a period of 5 years, there was no progression to chronic lymphocytic leukemia (CLL). Molecular analysis confirmed the presence of a BIRC3 mutation, which is associated with CLL but not typically seen in monoclonal B lymphocytosis (MBL). This case highlights the complexity of CLL evolution and represents the first reported case of BIRC3-mutated low-count MBL with long-term stability. [Extracted from the article]