부산대학교 도서관

Objectives: Medicinal herbs can be a good alternative for chemical drugs, considering their fewer side-effects and lower costs. Herbal preparation can be a good strategy to increase resistance to myocardial ischemia and reduce the severity of contractile dysfunction following ischemia. Sour cherry kernel extracts possess antioxidant compounds. Therefore, in this study, the protective effects of sour cherry kernel extracts on heart tissues were studied. Materials and Methods: In this study, 100, 250 and 500 mg/kg doses of sour cherry kernel extracts were produced, using nano microemulsion technique. First, the animals were anesthetized and connected to the ventilator device. Then, the chest was opened and the aorta was cannulated and connected to the Langendorff setup. Lactate dehydrogenase, creatine kinase, total antioxidant, glutathione peroxidase and superoxide dismutase were measured using a kit and the extent of heart damage was evaluated using the software. Results: The results showed that low doses of the extract did not have significant effects on antioxidant enzymes. On the other hand, the level of antioxidant enzymes significantly increased by using moderate or higher doses of the extract. Malondialdehyde level significantly reduced by using high doses of the extract. Also, different concentrations of the extract showed dose-dependent effects on reducing the extent of heart damage. Conclusion: The results showed that microemulsion of sour cherry kernel extract has preventive and protective effects on ischemic heart conditions by increasing antioxidant enzymes and decreasing lipid oxidation and the extent of heart damage. [ABSTRACT FROM AUTHOR]