학술논문
Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin.
Document Type
Article
Author
Source
Subject
*OOMYCETES
*CHEMICAL synthesis
*SAPROLEGNIA
*CHEMICAL derivatives
*MYCELIUM
*NUCLEAR magnetic resonance
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Language
ISSN
1420-3049
Abstract
An efficient synthesis of a series of 4'-oxyalkyl-isocordoin analogues (2-8) is reported for the first time. Their structures were confirmed by 1H-NMR, 13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 μg/mL and 75 μg/mL, respectively. The results showed that 4'-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents [ABSTRACT FROM AUTHOR]