부산대학교 도서관

Staphylococcus hominis is the third most frequent opportunistic pathogen in neonates and immunosuppressed patients that cause bacteremia, septicemia, endophthalmitis, and endocarditis. The emergence of methicillinresistant S. hominis (MRSHo) has been reported and is a growing concern. This review was intended to determine the susceptibility of S. hominis to antibiotic agents with a pharmacokinetics/pharmacodynamic approach. In addition, this review determined the phenotypic criteria and antibiotic choice of S. hominis infection. Four databases, namely PubMed, PlosOne, ScienceDirect, and Google Scholar were employed in the search process. Antibiotic resistance was identified using the minimum inhibitory concentration (MIC) and the percentage of resistance. The breakpoint value was based on The European Committee on Antimicrobial Susceptibility Testing (EUCAST) Breakpoint tables for interpretation of MIC and zone diameters Version 11.0. There were 876 articles identified, and 35 duplicates were removed. These gave a total of 841 articles screened yet 820 articles were irrelevant. Eventually, 21 articles were reviewed in this report. This review found that S. hominis potentially had MDR activity and a possible XDR bacterium that is resistant to some antibacterial agents. The susceptibility of antibiotics to bacteria is not identical, and the regional reported drug resistance varies commonly due to differences in environment and antibiotic use. The resistance profile of S. hominis is a complex interaction that is affected by multifactorial such as: pharmacokinetics/pharmacodynamics index, mutant prevention concentration (MPC), mutant selection window (MSW), and the capability to produce biofilm. [ABSTRACT FROM AUTHOR]