학술논문
European Society for Organ Transplantation (ESOT) Consensus Statement on the Role of Pancreas Machine Perfusion to Increase the Donor Pool for Beta Cell Replacement Therapy.
Document Type
Article
Author
Ferrer-Fàbrega, Joana; Mesnard, Benoît; Messner, Franka; Doppenberg, Jason B.; Drachenberg, Cinthia; Engelse, Marten A.; Johnson, Paul R. V.; Leuvenink, Henri G. D.; Oniscu, Gabriel C.; Papalois, Vassilios; Ploeg, Rutger J.; Reichman, Trevor W.; Scott III, William E.; Vistoli, Fabio; Berney, Thierry; Jacobs-Tulleneers-Thevissen, Daniel; Kessaris, Nicos; Weissenbacher, Annemarie; Ogbemudia, Ann Etohan; White, Steve
Source
Subject
*PANCREATIC beta cells
*TRANSPLANTATION of organs, tissues, etc.
*PANCREAS
*CELLULAR therapy
*PERFUSION
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Language
ISSN
0934-0874
Abstract
The advent of Machine Perfusion (MP) as a superior form of preservation and assessment for cold storage of both high-risk kidney's and the liver presents opportunities in the field of beta-cell replacement. It is yet unknown whether such techniques, when applied to the pancreas, can increase the pool of suitable donor organs as well as ameliorating the effects of ischemia incurred during the retrieval process. Recent experimental models of pancreatic MP appear promising. Applications of MP to the pancreas, needs refinement regarding perfusion protocols and organ viability assessment criteria. To address the "Role of pancreas machine perfusion to increase the donor pool for beta cell replacement," the European Society for Organ Transplantation (ESOT) assembled a dedicated working group comprising of experts to review literature pertaining to the role of MP as a method of improving donor pancreas quality as well as quantity available for transplant, and to develop guidelines founded on evidence-based reviews in experimental and clinical settings. These were subsequently refined during the Consensus Conference when this took place in Prague. [ABSTRACT FROM AUTHOR]