학술논문
Time dependence of cisplatin-induced duplex dissociation of 15-mer RNAs and mature miR-146a.
Document Type
Article
Source
Subject
*CISPLATIN
*DISSOCIATION (Chemistry)
*NON-coding RNA
*GENE expression
*APOPTOSIS
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Language
ISSN
1477-9226
Abstract
The kinetics for the binding of cisplatin to duplex RNAs, two fully complementary model systems and mature miR-146a, exhibits a linear dependence on cisplatin concentration and results in duplex dissociation at 38 °C. [ABSTRACT FROM AUTHOR]