부산대학교 도서관

• A systematic review and meta -analysis of pertussis vaccine effectiveness. • Receipt of any pertussis vaccine provided short-term protection against disease. • Estimates varied widely and heterogeneity in pooled estimates was high. • Heterogeneity was partially due to factors which may be mitigated by study design. A comprehensive review of observational pertussis vaccine effectiveness (VE) studies is needed to update gaps from previous reviews. We conducted a systematic review of VE and duration of protection studies for the whole-cell (wP) and acellular (aP) pertussis vaccines and conducted a formal meta -analysis using random effects models. Evidence continues to suggest that receipt of any pertussis vaccine confers protection in the short-term against disease although this protection wanes rapidly for aP vaccine. We detected significant heterogeneity in pooled estimates due, in part, to factors such as bias and confounding which may be mitigated by study design. Our review of possible sources of heterogeneity may help interpretation of other VE studies and aid design decisions in future pertussis VE research. [ABSTRACT FROM AUTHOR]