학술논문
Synthesis and Pharmacological Activity of Trifluoromethyl-Containing Imidazo[1,2- A]Benzimidazoles.
Document Type
Article
Author
Source
Subject
*BIOSYNTHESIS
*TRIFLUOROMETHYL compounds synthesis
*BENZIMIDAZOLES
*ACETONE
*CD26 antigen
*GLYCOGEN phosphorylase
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Language
ISSN
0091-150X
Abstract
A series of 2-(4-trifluoromethylphenyl)- and 2-trifluoromethyl-9-dialkylaminoalkylimidazo[1,2- a]benzimidazoles were synthesized for the first time by reacting 2-amino-1-dialkylaminoalkylbenzimidazoles and 2-bromo-1-[(4-trifluoromethyl)phenyl]ethanone or 1-bromo-3,3,3-trifluoroacetone and were tested for analgesic and antiplatelet activity, glycogen phosphorylase and dipeptidyl peptidase-4 inhibitory activity, and in vitro glycation of bovine serum albumin. [ABSTRACT FROM AUTHOR]