학술논문
Elevation of total homocysteine levels in patients with Parkinson's disease treated with duodenal levodopa/carbidopa gel.
Document Type
Article
Author
Source
Subject
*HOMOCYSTEINE
*PARKINSON'S disease patients
*DOPA
*PHARMACEUTICAL gels
*ATHEROSCLEROSIS
*POLYNEUROPATHIES
*MOVEMENT disorders
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Language
ISSN
0300-9564
Abstract
Levodopa/carbidopa (LD/CD) application elevates total plasma homocysteine (thcys). We determined thcys-, LD- and 3- O-methyldopa (3-OMD) concentrations in 28 patients with Parkinson's disease (PD) on a LD/CD duodenal gel treatment. We found a distinct thcys increase (29.52 ± 28.98 μmol/l [median ± SD]) above the 15 μmol/l threshold and a significant ( R = 0.7) correlation between LD and 3-OMD. thcys ascent was observed in relation with the onset of atherosclerosis, non-motor symptoms and polyneuropathy in PD patients in the long term. [ABSTRACT FROM AUTHOR]