학술논문
ERM proteins and merlin: integrators at the cell cortex.
Document Type
Article
Source
Subject
*MEMBRANE proteins
*PROTEINS
*CYTOSKELETON
*CELLULAR signal transduction
*CELL physiology
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Language
ISSN
1471-0072
Abstract
A fundamental property of many plasma-membrane proteins is their association with the underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and other plasma-membrane processes, including endocytosis and exocytosis. The ezrin?radixin?moesin (ERM) proteins are crucial components that provide a regulated linkage between membrane proteins and the cortical cytoskeleton, and also participate in signal-transduction pathways. The closely related tumour suppressor merlin shares many properties with ERM proteins, yet also provides a distinct and essential function. [ABSTRACT FROM AUTHOR]