학술논문
Study Blinding and Correlations Between Perceived Group Assignment and Outcome in a Cocaine Pharmacotherapy Trial.
Document Type
Article
Author
Source
Subject
*PSYCHIATRIC drugs
*COCAINE abuse treatment
*SUBSTANCE abuse
*AMANTADINE
*PROPRANOLOL
*DRUG abuse treatment
*THERAPEUTICS
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Language
ISSN
1055-0496
Abstract
While much research has suggested that the integrity of the blind is compromised in psychotropic drug trials, little research has been conducted on blinding in substance abuse trials. The current study examines the integrity of the blind in an outpatient pharmacotherapy trial investigating the effectiveness of amantadine and propranolol in treating cocaine addiction. Results suggest that neither nurses (N = 174, kappa = 0.08, p = 0.22) nor participants (N = 163, kappa = 0.09, p = 0.26) could accurately predict treatment assignment. Furthermore, nurses' perceptions of treatment assignment were significantly related to trial completion, medication compliance, and cocaine use—results that may have training implications for medical personnel. [ABSTRACT FROM AUTHOR]