부산대학교 도서관

This research was aimed to prepare and evaluate the matrix tablet of Metformin, to overcome its poor biopharmaceutical property and therapeutic efficacy. Metformin is biguanide derivatives of the antihyperglycemic category. Although metformin shows excellent water solubility after reaching the gastrointestinal tract, the drug values are lower in the plasma. This indicates that metformin has very low bioavailability (1-2.5 hours). To prolong the duration of action and also to improve patient compliance; it is formulated into a matrix tablet. The overall objective of this research work was to develop a matrix tablet of metformin to sustain its action by using polymers of different ratios such as Starch 1500, HPMC, K4M, Crospovidone XL, MCC 102. The tablet was formulated using the wet granulation technique. Invitro drug dissolution study was performed to estimate the amount of drug released from the prepared matrix tablet. The drug release study revealed that crospovidone XL and MCC 102 in ration 2:1 were best suited as a matrix tablet giving a release rate of 86% for 9hrs by using selected grades of HPMC at selected proportion. The experimental and predicted results for optimum formulations were found to be in close agreement. [ABSTRACT FROM AUTHOR]