학술논문
Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics.
Document Type
Article
Author
Source
Subject
*AMOXICILLIN
*BETA lactam antibiotics
*CEFOTAXIME
*DISEASE susceptibility
*DRUG resistance in microorganisms
*GENETIC mutation
*PROTEINS
*STREPTOCOCCUS
*AMPICILLIN
*
*
*
*
*
*
*
*
Language
ISSN
1058-4838
Abstract
Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin were 8-fold higher, and the MIC for cefotaxime was 3-fold higher than for near-isogenic control isolates, consistent with a first step in developing β-lactam resistance. [ABSTRACT FROM AUTHOR]