학술논문
Adenovirus-specific immunity after immunization with an Ad5 HIV-1 vaccine candidate in humans.
Document Type
Article
Author
Source
Subject
*ADENOVIRUS diseases
*ADENOVIRUSES
*AIDS vaccines
*IMMUNITY
*IMMUNIZATION
*VACCINATION
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*
*
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Language
ISSN
1078-8956
Abstract
The immunologic basis for the potential enhanced HIV-1 acquisition in adenovirus serotype 5 (Ad5)-seropositive individuals who received the Merck recombinant Ad5 HIV-1 vaccine in the STEP study remains unclear. Here we show that baseline Ad5-specific neutralizing antibodies are not correlated with Ad5-specific T lymphocyte responses and that Ad5-seropositive subjects do not develop higher vector-specific cellular immune responses as compared with Ad5-seronegative subjects after vaccination. These findings challenge the hypothesis that activated Ad5-specific T lymphocytes were the cause of the potential enhanced HIV-1 susceptibility in the STEP study. [ABSTRACT FROM AUTHOR]