학술논문
Combination of selol nanocapsules and magnetic hyperthermia hinders breast tumor growth in aged mice after a short-time treatment.
Document Type
Article
Author
Pinheiro, Willie Oliveira; Costa do Santos, Mayara Simonelly; Farias, Gabriel Ribeiro; Fascineli, Maria Luiza; Ramos, Khellida Loiane Vieira; Duarte, Eliza Carla Barroso; Damasceno, Emanuel Adelino Medeiros; da Silva, Jaqueline Rodrigues; Joanitti, Graziella Anselmo; de Azevedo, Ricardo Bentes; Sousa, Marcelo Henrique; Lacava, Zulmira Guerrero Marques; Mosiniewicz-Szablewska, Ewa; Suchocki, Piotr; Morais, Paulo Cesar; de Andrade, Laise Rodrigues
Source
Subject
*TUMOR growth
*BREAST tumors
*NANOCAPSULES
*FEVER
*OLDER patients
*TRANSCRANIAL magnetic stimulation
*BREAST
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Language
ISSN
0957-4484
Abstract
Short time treatment with reduced dosages of selol-loaded PLGA nanocapsules (NcSel) combined with magnetic hyperthermia (MHT) is evaluated in aged Erhlich tumor-bearing mice. Clinical, hematological, biochemical, genotoxic and histopathological parameters are assessed during 7 d treatment with NcSel and MHT, separately or combined. The time evolution of the tumor volume is successfully modeled using the logistic mathematical model. The combined therapy comprising NcSel and MHT is able to hinder primary tumor growth and a case of complete tumor remission is recorded. Moreover, no metastasis was diagnosed and the adverse effects are negligible. NcSel plus MHT may represent an effective and safe alternative to cancer control in aged patients. Future clinical trials are encouraged. [ABSTRACT FROM AUTHOR]