학술논문
Succinate metabolism and membrane reorganization drives the endotheliopathy and coagulopathy of traumatic hemorrhage.
Document Type
Article
Author
Abdullah, Sarah; Ghio, Michael; Cotton-Betteridge, Aaron; Vinjamuri, Aditya; Drury, Robert; Packer, Jacob; Aras, Oguz; Friedman, Jessica; Karim, Mardeen; Engelhardt, David; Kosowski, Emma; Duong, Kelby; Shaheen, Farhana; McGrew, Patrick R.; Harris, Charles T.; Reily, Robert; Sammarco, Mimi; Chandra, Partha K.; Pociask, Derek; Kolls, Jay
Source
Subject
*ISOFLURANE
*BLOOD coagulation factors
*CLINICAL chemistry
*ATMOSPHERIC carbon dioxide
*BLOOD coagulation disorders
*PEARSON correlation (Statistics)
*BIOLOGICAL membranes
*POLYBUTENES
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Language
ISSN
2375-2548
Abstract
The article discusses the role of succinate metabolism and membrane reorganization in driving coagulopathy during traumatic hemorrhage. Succinate accumulation leads to glycocalyx degradation through lipid oxidation and membrane changes. Inhibiting succinate metabolism prevents damage and holds promise for treating coagulopathy in traumatic hemorrhage.