학술논문
Structural and functional specializations of human fastspiking neurons support fast cortical signaling.
Document Type
Article
Author
Wilbers, René; Galakhova, Anna A.; Driessens, Stan L. W.; Heistek, Tim S.; Metodieva, Verjinia D.; Hagemann, Jim; Heyer, Djai B.; Mertens, Eline J.; Suixin Deng; Idema, Sander; de Witt Hamer, Philip C.; Noske, David P.; van Schie, Paul; Kommers, Ivar; Guoming Luan; Tianfu Li; Yousheng Shu; de Kock, Christiaan P. J.; Mansvelder, Huibert D.; Goriounova, Natalia A.
Source
Subject
*INTERNEURONS
*SODIUM channels
*NEURONS
*EXCITATORY postsynaptic potential
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Language
ISSN
2375-2548
Abstract
The article focuses on understanding the mechanisms underlying fast cortical signaling in human fast-spiking interneurons (FSINs). The study compares human and mouse FSINs, revealing that despite elongated dendrites in human FSINs, they maintain fast inhibition through adaptations such as stronger excitatory inputs, larger dendrite diameter with reduced complexity, faster action potential initiation, and faster and larger inhibitory output.