학술논문
HCV infection characteristics, treatment uptake and outcomes in patient with diabetes mellitus.
Document Type
Article
Source
Subject
*AGE distribution
*HEPATITIS C
*ANTIRETROVIRAL agents
*RETROSPECTIVE studies
*ACQUISITION of data
*CIRRHOSIS of the liver
*TREATMENT effectiveness
*PATIENTS' attitudes
*HIGHLY active antiretroviral therapy
*COMPARATIVE studies
*T-test (Statistics)
*MEDICAL records
*CHI-squared test
*DESCRIPTIVE statistics
*DISEASE prevalence
*EMPLOYMENT
*LOGISTIC regression analysis
*LONGITUDINAL method
*SYMPTOMS
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Language
ISSN
1472-6823
Abstract
Background: The interplay between HCV, DM, and DAA therapy is poorly understood. We compared HCV infection characteristics, treatment uptake, and treatment outcomes in patients with and without DM. Methods: A retrospective cohort study was conducted using data from The Ottawa Hospital Viral Hepatitis Program. Statistical comparisons between diabetes and non-diabetes were made using χ2 and t-tests. Logistic regression analyses were performed to assess predictors of DM and SVR. Results: One thousand five hundred eighty-eight HCV patients were included in this analysis; 9.6% had DM. Patients with DM were older and more likely to have cirrhosis. HCC and chronic renal disease were more prevalent in the DM group. Treatment uptake and SVR were comparable between groups. Regression analysis revealed that age and employment were associated with achieving SVR. Post-SVR HCC was higher in DM group. Conclusion: The high prevalence of DM in our HCV cohort supports screening. Further assessment is required to determine if targeted, early DAA treatment reduces DM onset, progression to cirrhosis and HCC risk. Further studies are needed to determine if optimization of glycemic control in this population can lead to improved liver outcomes. [ABSTRACT FROM AUTHOR]