학술논문
Pregnancy and multiple sclerosis: 2022 recommendations from the French multiple sclerosis society.
Document Type
Article
Author
Vukusic, Sandra; Carra-Dalliere, Clarisse; Ciron, Jonathan; Maillart, Elisabeth; Michel, Laure; Leray, Emmanuelle; Guennoc, Anne-Marie; Bourre, Bertrand; Laplaud, David; Androdias, Géraldine; Bensa, Caroline; Bigaut, Kevin; Biotti, Damien; Branger, Pierre; Casez, Olivier; Cohen, Mikael; Daval, Elodie; Deschamps, Romain; Donze, Cécile; Dubessy, Anne-Laure
Source
Subject
*MULTIPLE pregnancy
*MULTIPLE sclerosis
*SCIENTIFIC literature
*CHILDBEARING age
*YOUNG women
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Language
ISSN
1352-4585
Abstract
Objective: The objective of this study was to develop evidence-based recommendations on pregnancy management for persons with multiple sclerosis (MS). Background: MS typically affects young women in their childbearing years. Increasing evidence is available to inform questions raised by MS patients and health professionals about pregnancy issues. Methods: The French Group for Recommendations in Multiple Sclerosis (France4MS) reviewed PubMed and university databases (January 1975 through June 2021). The RAND/UCLA appropriateness method was developed to synthesise the scientific literature and expert opinions on healthcare topics; it was used to reach a formal agreement. Fifty-six MS experts worked on the full-text review and initial wording of recommendations. A group of 62 multidisciplinary healthcare specialists validated the final proposal of summarised evidence. Results: A strong agreement was reached for all 104 proposed recommendations. They cover diverse topics, such as pregnancy planning, follow-up during pregnancy and postpartum, delivery routes, locoregional analgesia or anaesthesia, prevention of postpartum relapses, breastfeeding, vaccinations, reproductive assistance, management of relapses and disease-modifying treatments. Conclusion: The 2022 recommendations of the French MS society should be helpful to harmonise counselling and treatment practice for pregnancy in persons with MS, allowing for better and individualised choices. [ABSTRACT FROM AUTHOR]