학술논문
Mucus plugging on computed tomography and chronic bronchitis in chronic obstructive pulmonary disease.
Document Type
Letter
Author
Kim, Victor; Dolliver, Wojciech R.; Nath, Hrudaya P.; Grumley, Scott A.; Terry, Nina; Ahmed, Asmaa; Yen, Andrew; Jacobs, Kathleen; Kligerman, Seth; Diaz, Alejandro A.; the COPDGene Investigators; Crapo, James D.; Silverman, Edwin K.; Make, Barry J.; Regan, Elizabeth A.; Beaty, Terri; Begum, Ferdouse; Castaldi, Peter J.; Cho, Michael; DeMeo, Dawn L.
Source
Subject
*OBSTRUCTIVE lung diseases
*COMPUTED tomography
*CHRONIC bronchitis
*MUCUS
*
*
*
Language
ISSN
1465-9921
Abstract
Chronic bronchitis (CB) is associated with more dyspnea, increased respiratory exacerbations, reduced exercise capacity, and mortality [[1]]. Mucus plugging (MP) on CT scan has been associated with decreased lung function, worse health-related quality of life, and amount of emphysema in Chronic Obstructive Pulmonary Disease (COPD) [[3]]. MP+ was associated with an OR of 1.21 and 1.38 for classic CB and SGRQ CB, respectively when adjusting for demographics, lung function, smoking, and CT measures of emphysema and airway wall thickness. In the MP >= 4 group, the differences were more significant with 57.7% and 41.4% of the subjects having SGRQ CB and classic CB, respectively, compared to 27.6% and 23.8% of the MP < 4 group. [Extracted from the article]