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Keywords: guidelines; myocardial infarction; peri-operative risk; transfusion mortality: causes Nordestgaard et al. also speculate that adherence to restrictive transfusion practices, which have become increasingly popular since 2010, may have contributed to a reduction in red blood cell transfusion rates and they point to a lower pre-transfusion haematocrit at the end of the study period in Fig. Although restrictive transfusion thresholds lead to fewer red blood cell transfusions, is haemoglobin or haematocrit the best indicator for a transfusion? Risk of acute kidney injury in patients randomized to a restrictive versus liberal approach to red blood transfusion in cardiac surgery: a substudy protocol of the transfusion requirements in cardiac surgery 3 noninferiority trial. [Extracted from the article]