학술논문
The prognostic impact of lymphoma perforation in patients with primary gastrointestinal lymphoma – a single-center analysis.
Document Type
Article
Author
Source
Subject
*LYMPHOMAS
*PROGRESSION-free survival
*SURGICAL emergencies
*OVERALL survival
*TREATMENT delay (Medicine)
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Language
ISSN
1042-8194
Abstract
Patients with primary gastrointestinal (GI) lymphoma are at risk of GI perforations. Therefore, we aimed to investigate the prognostic impact of non-traumatic GI perforations. 54 patients with a histologically confirmed diagnosis of primary GI lymphoma were included. Non-traumatic lymphoma perforation occurred in ten patients (19%). Perforations occurred only in patients with aggressive B-cell lymphoma. In patients with aggressive B-cell lymphoma, the median overall survival (mOS) was 52 months (95% CI 9.88–94.12) and 27 months (95% CI 0.00–135.48) in patients with and without GI perforation, respectively. The median progression-free survival (mPFS) was 30 months (95% CI 5.6–54.4) in patients with GI perforations. In patients without lymphoma perforation, mPFS was not reached. Both mOS and mPFS did not significantly differ. In conclusion, despite the need for emergency surgery and delay in lymphoma-directed treatment, lymphoma perforation did not negatively impact our study population's OS or PFS. [ABSTRACT FROM AUTHOR]