학술논문
The mutational landscape of Hodgkin lymphoma cell lines determined by whole-exome sequencing.
Document Type
Article
Author
Source
Subject
*HODGKIN'S disease
*CELL lines
*HUMAN leucocytes
*ANTIGENS
*IMMUNITY
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Language
ISSN
0887-6924
Abstract
The article presents a study which conducts whole-exome sequencing (WES) in seven cell lines to determine commonly mutated genes in Hodgkin lymphoma (HL). It states that based on PolyPhen2 and SIFT analyses, cell lines have all been based from patients with end-stage disease and as such may contain treatment-induced mutations in addition to possible cell line artifact. It is inferred that the mechanisms responsible for the human leukocyte antigen (HLA) loss is uncertain.