학술논문
No Adaptation of the Prion Strain in a Heterozygous Case of Variant Creutzfeldt-Jakob Disease.
Document Type
Journal Article
Author
Source
Subject
*CREUTZFELDT-Jakob disease
*BOVINE spongiform encephalopathy
*PRIONS
*CHRONIC wasting disease
*PRION diseases
*PHYSIOLOGICAL adaptation
*CREUTZFELDT-Jakob disease diagnosis
*RESEARCH
*CATTLE
*ANIMAL experimentation
*RESEARCH methodology
*MEDICAL cooperation
*EVALUATION research
*COMPARATIVE studies
*GENES
*RESEARCH funding
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Language
ISSN
1080-6040
Abstract
We investigated a clinical case of variant Creutzfeldt-Jakob Disease in a person heterozygous for methionine/valine at codon 129 of the prion protein gene and identified the same strain properties in variant Creutzfeldt-Jakob disease in methionine homozygous persons and in bovine spongiform encephalopathy. These results indicate no adaptation of the agent in a different genetic background. [ABSTRACT FROM AUTHOR]