학술논문
Protective Efficacy of Lyophilized Vesicular Stomatitis Virus-Based Vaccines in Animal Model.
Document Type
Article
Author
Source
Subject
*VESICULAR stomatitis
*ANIMAL models in research
*VACCINES
*GUINEA pigs
*FREEZE-drying
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Language
ISSN
1080-6040
Abstract
We evaluated the in vitro effects of lyophilization for 2 vesicular stomatitis virus-based vaccines by using 3 stabilizing formulations and demonstrated protective immunity of lyophilized/reconstituted vaccine in guinea pigs. Lyophilization increased stability of the vaccines, but specific vesicular stomatitis virus-based vaccines will each require extensive analysis to optimize stabilizing formulations. [ABSTRACT FROM AUTHOR]