학술논문
Low-Dose Colchicine in Patients With Type 2 Diabetes and Recent Myocardial Infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT).
Document Type
Article
Author
Roubille, François; Bouabdallaoui, Nadia; Kouz, Simon; Waters, David D.; Diaz, Rafael; Maggioni, Aldo P.; Pinto, Fausto J.; Grégoire, Jean C.; Gamra, Habib; Kiwan, Ghassan S.; Berry, Colin; López-Sendón, José; Koenig, Wolfgang; Delorme, Laurent; Elbaz, Meyer; Coste, Pierre; Provencher, Mylène; Bassevitch, Zohar; Blondeau, Lucie; L’Allier, Philippe L.
Source
Subject
*TYPE 2 diabetes
*MYOCARDIAL infarction
*COLCHICINE
*CORONARY disease
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Language
ISSN
0149-5992
Abstract
OBJECTIVE: The cardiovascular benefits of low-dose colchicine have been demonstrated in patients with coronary disease. Its effects were evaluated in this prespecified analysis in patients with type 2 diabetes (T2D) from the Colchicine Cardiovascular Outcomes Trial (COLCOT). RESEARCH DESIGN AND METHODS: COLCOT was a randomized, double-blinded trial of colchicine, 0.5 mg daily, versus placebo initiated within 30 days after a myocardial infarction. RESULTS: There were 959 patients with T2D enrolled and monitored for a median of 22.6 months. A primary end point event occurred in 8.7% of patients in the colchicine group and in 13.1% in the placebo group (hazard ratio 0.65; 95% CI 0.44–0.96; P = 0.03). Nausea was reported in 2.7% and 0.8% in the study groups (P = 0.03), and pneumonia occurred in 2.4% and 0.4% (P = 0.008). CONCLUSIONS: Among patients with T2D and a recent myocardial infarction, colchicine, 0.5 mg daily, leads to a large reduction of cardiovascular events. These results support the conduct of the COLCOT-T2D trial in primary prevention. [ABSTRACT FROM AUTHOR]