학술논문
Nanovectorization of DNA Through Cells Using Protamine Complexation.
Document Type
Journal Article
Author
Source
Subject
*PROTAMINES
*NANOCARRIERS
*CARBON nanotubes
*DRUG development
*GENETIC vectors
*COMPLEXATION reactions
*MOLECULAR dynamics
*ADSORPTION (Chemistry)
*ANIMALS
*BIOLOGICAL transport
*CHEMICAL elements
*COMPUTER simulation
*DNA
*MATHEMATICAL models
*MOLECULAR structure
*NANOPARTICLES
*PARTICLES
*THEORY
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Language
ISSN
0022-2631
Abstract
Carbon nanotubes (CNT) are currently used as a promising family of nanovectors able to deliver different types of therapeutic molecules. Several applications dealing with CNT used as drug nanocarriers have been developed since their ability to penetrate into the cells has been proved. CNT can thus load several active molecules to various cells. In this paper, we will use molecular dynamic simulation to describe theoretically the potential of CNT to transport and deliver DNA through the formation of protamine-DNA-CNT complex. [ABSTRACT FROM AUTHOR]